"Test me and treat me" - attitudes to vitamin D deficiency and supplementation: a qualitative study

© 2015 BMJ Open, "Test me and treat me"-attitudes to vitamin D deficiency and supplementation: a qualitative study. This manuscript version is made available under the Creative Commons Attribution Licens

Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat

Case summary A 15-year-old female cat was presented for investigation of progressive behavioural changes, polyuria, polydipsia and periuria. An ovarian granulosa cell tumour was identified and the cat underwent therapeutic ovariohysterectomy (OHE). The cat’s clinical signs resolved, but 6 months later it was diagnosed as having an anaplastic astrocytoma and was euthanased. Serum anti-Müllerian hormone (AMH) concentration prior to OHE was increased vs a control group of entire and neutered female cats. Following OHE, serum AMH concentration decreased to <1% of the original value. Relevance and novel information Serum AMH measurement may represent a novel diagnostic and monitoring tool for functional ovarian neoplasms in cats

320g Ionization-Heat Cryogenic Detector for Dark Matter Search in the EDELWEISS Experiment

The EDELWEISS experiment used in 2001 a 320g heat-and-ionization cryogenic Ge detector operated in a low-background environment in the Laboratoire Souterrain de Modane for direct WIMP detection. This detector presents an increase of more than 4 times the mass of previous detectors. Calibrations of this detector are used to determine its energy resolution and fiducial volume, and to optimize the detector design for the 1kg phase of the EDELWEISS-I experiment. Analysis of the calibrations and characteristics of a first series of 320g-detectors are presented.Comment: 4 pages, 3 figure

Decoherence in the cosmic background radiation

In this paper we analyze the possibility of detecting nontrivial quantum phenomena in observations of the temperature anisotropy of the cosmic background radiation (CBR), for example, if the Universe could be found in a coherent superposition of two states corresponding to different CBR temperatures. Such observations are sensitive to scalar primordial fluctuations but insensitive to tensor fluctuations, which are therefore converted into an environment for the former. Even for a free inflaton field minimally coupled to gravity, scalar-tensor interactions induce enough decoherence among histories of the scalar fluctuations as to render them classical under any realistic probe of their amplitudes.Comment: 15 pages, accepted to be published in Classical and Quantum Gravit

The implementation and acceptance of yoga techniques for children with complex trauma among practicing clinicians

This mixed-method study was undertaken to determine acceptance and utilization rates of yoga techniques in treatment with children ages 5-17, with complex trauma among practicing-clinicians. Secondly, it was to explore beliefs of effectiveness and barriers of implementation of yoga in a therapeutic milieu. An online survey was sent through mass emails of local agencies, online social media sites through groups associated with trauma and mental health to determine practicing therapists\u27 interests, utilization, beliefs of effectiveness, and barriers of implementation of yoga techniques in therapeutic practice with children with complex trauma. To qualify to participate in this study, one had to be a practicing clinician who works with children ages 5-17 with complex trauma. The survey consisted of both quantitative and qualitative data that asked for the demographics of the participants, their interests in utilizing yoga in treatment, their beliefs of the effectiveness of utilizing yoga in treatment, their current utilization rates, and further explored, through open ended questions, what some of their experiences were and their beliefs of effectiveness in utilizing techniques in treatment. The findings revealed that a majority of the participants were interested in utilizing yoga for the treatment of trauma; however, implementing these techniques in practice was a challenge for most clinicians. A majority of the participants believed that lack of knowledge or training was a barrier for implementation, and further research needs to be conducted to determine how agencies could provide opportunities for practicing therapists to effectively utilize yoga techniques in their therapeutic practice with children

Can Action Research Strengthen District Health Management and Improve Health Workforce Performance? A Research Protocol.

The single biggest barrier for countries in sub-Saharan Africa (SSA) to scale up the necessary health services for addressing the three health-related Millennium Development Goals and achieving Universal Health Coverage is the lack of an adequate and well-performing health workforce. This deficit needs to be addressed both by training more new health personnel and by improving the performance of the existing and future health workforce. However, efforts have mostly been focused on training new staff and less on improving the performance of the existing health workforce. The purpose of this paper is to disseminate the protocol for the PERFORM project and reflect on the key challenges encountered during the development of this methodology and how they are being overcome. The overall aim of the PERFORM project is to identify ways of strengthening district management in order to address health workforce inadequacies by improving health workforce performance in SSA. The study will take place in three districts each in Ghana, Tanzania and Uganda using an action research approach. With the support of the country research teams, the district health management teams (DHMTs) will lead on planning, implementation, observation, reflection and redefinition of the activities in the study. Taking into account the national and local human resource (HR) and health systems (HS) policies and practices already in place, 'bundles' of HR/HS strategies that are feasible within the context and affordable within the districts' budget will be developed by the DHMTs to strengthen priority areas of health workforce performance. A comparative analysis of the findings from the three districts in each country will add new knowledge on the effects of these HR/HS bundles on DHMT management and workforce performance and the impact of an action research approach on improving the effectiveness of the DHMTs in implementing these interventions. Different challenges were faced during the development of the methodology. These include the changing context in the study districts, competing with other projects and duties for the time of district managers, complexity of the study design, maintaining the anonymity and confidentiality of study participants as well as how to record the processes during the study. We also discuss how these challenges are being addressed. The dissemination of this research protocol is intended to generate interest in the PERFORM project and also stimulate discussion on the use of action research in complex studies such as this on strengthening district health management to improve health workforce performance

The Effects of Gravitational Back-Reaction on Cosmological Perturbations

Because of the non-linearity of the Einstein equations, the cosmological fluctuations which are generated during inflation on a wide range of wavelengths do not evolve independently. In particular, to second order in perturbation theory, the first order fluctuations back-react both on the background geometry and on the perturbations themselves. I this paper, the gravitational back-reaction of long wavelength (super-Hubble) scalar metric fluctuations on the perturbations themselves is investigated for a large class of inflationary models. Specifically, the equations describing the evolution of long wavelength cosmological metric and matter perturbations in an inflationary universe are solved to second order in both the amplitude of the perturbations and in the slow roll expansion parameter. Assuming that the linear fluctuations have random phases, we show that the fractional correction to the power spectrum due to the leading infrared back-reaction terms does not change the shape of the spectrum. The amplitude of the effect is suppressed by the product of the inflationary slow-roll parameter and the amplitude of the linear power spectrum. The non-gaussianity of the spectrum induced by back-reaction is commented upon.Comment: 9 page

The CXCL12/CXCR4 Axis Plays a Critical Role in Coronary Artery Development

The chemokine CXCL12 and its receptor CXCR4 have many functions during embryonic and post-natal life. We used murine models to investigate the role of CXCL12/CXCR4 signaling in cardiac development and found that embryonic Cxcl12-null hearts lacked intra-ventricular coronary arteries (CAs) and exhibited absent or misplaced CA stems. We traced the origin of this phenotype to defects in the early stages of CA stem formation. CA stems derive from the peritruncal plexus, an encircling capillary network that invades the wall of the developing aorta. We showed that CXCL12 is present at high levels in the outflow tract, while peritruncal endothelial cells (ECs) express CXCR4. In the absence of CXCL12, ECs were abnormally localized and impaired in their ability to anastomose with the aortic lumen. We propose that CXCL12 is required for connection of peritruncal plexus ECs to the aortic endothelium and thus plays a vital role in CA formation